A Cu[I] catalyzed mild and general synthesis of 1,4-disubstituted-1,2,3-triazoles from terminal acetylenes and in situ generated alkyl azides.
Lopez Ruiz, Heraclio
2014
A Cu[I] catalyzed mild and general synthesis of 1,4-disubstituted-1,2,3-triazoles from terminal acetylenes and in situ generated alkyl azides. José Emilio de la Cerda-Pedro, Yoarhy Alejandro Amador-Sánchez, Mayra Cortés-Hernández, Jovana Pérez-Pérez, Susana Rojas-Lima and Heraclio López-Ruiz,Heterocycles 89, 27-41 (2014). DOI: 10.3987/COM-13-12764.
Abstract
Cuprous cyanide, generated in situ from cupric sulfate and sodium cyanide, catalyzes the synthesis of 1,4-disubstituted-1,2,3-triazoles from in situ generated alkyl azides and mono-substituted alkynes in a one pot room temperature process.
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