Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides
Rojas Lima, Susana
2015
José Emilio de la Cerda-Pedro, Susana Rojas-Lima, Rosa Santillan and Heraclio López-Ruiz*, Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides, J. Mex. Chem. Soc. 2015, 59(2), 130-136.
Abstract
The synthesis of 1,4-disubstituted-1,2,3-triazoles from alkylazides and terminal alkynes at room temperature and under microwaveheating was attained using Cu(I), generated in-situ fromcopper(II) sulfate and phenylboronic acid, as catalyst. Twelve newtriazoles were obtained in moderate to good yields (53-98%), and theproducts were obtained by crystallization from the mixture reactionwithout further purification.
Related articles
Study of the reactivity of squarylferrocenes. Addition of amines and aminoesters
Preparation of N-aryl-substituted spiro-?-lactams via Staudinger cycloaddition
The Structural Chemistry of N-Monolithium Borazines
Et3B, an Efficient Mediator for Xanthate Transfer Based Radical Processes
Et3, and efficient Mediator for Xanthate Transfer Based Radical Processes.
Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.