Synthesis of Acetamido(indole-3-yl)propanol Derivatives

A series of acetamido(indole-3-yl)propanol derivatives (5-7) have been synthesized using a variety of reductive reactions performed on the corresponding O-methyl oximes of an indole-3-yl ester and of several indole-3-yl alcohol derivatives. The O-methyl oximes were prepared in good yields by acylation of the corresponding zinc salt of indole, followed by O-methyl oximation.